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By Arthur M. Silverstein

It is a professional-level highbrow background of the advance of immunology from approximately 1720 to approximately 1970. starting with the paintings and insights of the early immunologists within the 18th century, Silverstein strains the advance of the foremost principles that have shaped immunology right down to the maturation of the self-discipline within the decade following the second one international battle. Emphasis is put on the philosophic and sociologic weather of the medical milieu within which immunology has constructed, supplying a historical past to the large tradition of the self-discipline.

Key Features
* A professional-level highbrow heritage of the improvement of immunology from approximately 1720 to 1970, with emphasis put on the social weather of the medical milieu during which smooth immunology evolved
* Written through an writer rather well recognized either as a historian of clinical technological know-how and for his sizeable learn contributions to the immunopathology of the eye
* the one whole background of immunology on hand

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14 A History of Immunology of the infection is used u p in the process, while in the other it is expelled from the body. THOMAS FULLER, 1 7 3 0 , AND THE INNATE SEED T h e seventeenth and eighteenth centuries saw the development of many interesting notions about the etiology and pathogenesis of infectious disease. Perhaps none was quite as fanciful as the concept of the "innate seed," whose fertilization was thought to give birth to the disease process itself. In the context of smallpox and of acquired immunity, it was presented most elegantly by Thomas Fuller: 37 Nature, in the first compounding and forming of us, hath laid into the Substance and constitution of each something equivalent to Ovula, of various distinct Kinds, productive of all the contagious, venomous Fevers we can possibly have as long as we live.

37, fol. 15, Bodleian Library, Oxford; quoted in Steams and Pasti, ref. 6, p. 107. 9. Journal Book IX, Royal Society Library, p. 194. 10. Philos. Trans. R. Soc. London 29(339), 72 (1714). 11. Philos. Trans. R. Soc. London 29(347), 393 (1716). 12. J. B. Blake, T h e inoculation controversy in Boston: 1721-1722. N. Engl. Q. 25, 490 (1952). See also G. L. Kittredge, Introduction to Increase Mather's, "Several Reasons Proving that Inoculating or Transplanting the Small Pox, Is a Lawful Practice, and That It Has Been Blessed by God for the Saving of Many a Life" (1721).

Sei. 90, 239 (1880). 44. P. Ehrlich, Experimental Researches on Specific Therapeutics. Lewis, London, 1908. 45. E. Sauerbeck, Die Krise in der Immunitätsforschung. Klinkhardt, Leipzig, 1909. 46. E. Metchnikoff, Lectures on the Comparative Pathology of Inflammation. Keegan, Paul, Trench, Trübner, London, 1893. ] 47. M. von N e n c k i J . Prakt. Chem. May (1879); cited in Sirotinin, Z. Hyg. 4, 262 (1888). 48. A. Chauveau, C. R. Hebd. Seances Acad. Sei. 89,498 (1880); 90, 1526 (1880); 91, 148 (1880).

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