By Nobuyo Maeda, Nobuo Tamiya, Y. M. Chen, C. Y. Lee (auth.), Akira Ohsaka, Kyozo Hayashi, Yoshio Sawai, Ryosuke Murata, Masaru Funatsu, Nobuo Tamiya (eds.)
During the prior twenty years, study on animal, plant, and microbial pollutants has accelerated swiftly, and new and fascinating info has seemed to make clear either the scientific and healing features of intoxication and, much more impor tant, to aid us comprehend extra precisely the constitution and the mode of motion of poisons on a molecular foundation. as a result interdisciplinary nature of toxin learn, it really is of important impor tance that staff focusing on its various points should still make a specific attempt to switch and stay alongside of new advancements during this rapidly-expanding box. This has been one of many major reasons of the sequence of overseas conferences which were held over the last ten years. The expanding curiosity within the result of toxin study could be defined partially by way of the starting to be basic preoccupation with pollutants and its poisonous results, which means extra anq extra experts in different fields are discovering it essential to keep up a correspondence with present study into clearly happening pollution. The papers in those volumes have been offered on the Fourth foreign Symposium on Animal, Plant and Microbial pollutants, geared up by way of the Inter nationwide Society on Toxicology, held in Tokyo in September, 1974. The editors have made up our minds to incorporate either unique experiences and evaluation articles, prepared in line with disciplines. modifying has been stored to the minimal invaluable for enough comprehension of the materials.
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Additional info for Animal, Plant, and Microbial Toxins: Volume 2 Chemistry, Pharmacology, and Immunology
J. (1973). Snake venom toxins, Structure-function relationships and phylogenetics, Compo Biochem. Physiol. 44B: 269-281. Strydom, A. J. C. and Botes, D. P. (1971). Snake venom toxins. Purification, properties and complete amino acid sequences of two toxins from Ringhals (Haemachatus haemachatus) venom,]. BioI. Chem. 246: 1341-1349. Takechi,. , and Hayashi, K. (1972). Localization of the four disulfide bridges in cytotoxin II from the venom of the Indian cobra (Naja naja), Biochem. Biophys. Res.
The study of the effect of chemical modification of a specific group, however, must be accompanied by the evidence of conformational reservation of the toxin molecule. The second method relies on the chance that all of the nonessential residues are replacable by others. The elucidation of the structures of weakly acting toxins or inactive components, which are synthesized by the animals themselves, provides a new approach to the clarification of the essential structure of the active toxins. SUMMARY A weakly neurotoxic component (LsIn) has been isolated by CM-cellulose column chromatography from the venom of a sea snake, L.
Chymotryptic peptides were separated chromatographically and electrophoretically. The tryptic digest of the carboxymethylated cytotoxin was fractionated on Chromo-Beads P4 under the conditions similar to those used for neurotoxin II. Eleven peptides were isolated from the digest; their amino acid composition is shown in Table 5. All of the described results allowed us to construct the amino acid sequence of the cytotoxin (Fig. 5). We can now conclude that the cytotoxin from the N. n. oxiana venom is homologous with the cytotoxins and cardiotoxins from the venoms of other cobras.