Download Annual Review of Immunology Volume 20 2002 by Annual Reviews PDF

  • admin
  • June 29, 2017
  • Immunology
  • Comments Off on Download Annual Review of Immunology Volume 20 2002 by Annual Reviews PDF

By Annual Reviews

Show description

Read or Download Annual Review of Immunology Volume 20 2002 PDF

Best immunology books

Color Atlas of Immunocytochemistry in Diagnostic Cytology P Ganjei Azar M Nadji

Lately, cytology has performed an more and more vital position within the prognosis of illness, relatively these of neoplastic beginning. it isn't strange for cytologic specimens to be the single diagnostic samples on hand from sufferers with melanoma. Many ancillary assessments commonly played on histologic fabric at the moment are being played on cytologic specimens.

Antibody Methods and Protocols

The swiftly growing to be box of antibody learn is the results of many advancing applied sciences permitting present advancements to exploit molecular engineering to create tailored antibodies. Antibody tools and Protocols makes an attempt to supply perception into the iteration of antibodies utilizing in vitro and in vivo techniques, in addition to technical points for screening, research, and amendment of antibodies and antibody fragments.

Gene Therapy for HIV and Chronic Infections

This ebook facilities on gene remedy and gene move ways to avoid or deal with persistent virus infections. the main target is at the vast 3: human immunodeficiency virus (HIV-1), hepatitis B virus (HBV) and hepatitis C virus (HCV). plentiful anti-HIV medicines are presently to be had within the health center and the improvement of an efficient mixture remedy has dramatically superior the lifespan and caliber of lifetime of contaminated contributors.

Extra resources for Annual Review of Immunology Volume 20 2002

Sample text

SGM LaTeX2e(2001/05/10) P1: GSR Annu. Rev. Immunol. 20:29-53. org by HINARI on 09/01/07. For personal use only. NEW B7-LIKE LIGANDS AND RECEPTORS 41 et al. (74) reported that PD-L2 (B7-DC) transcripts are exclusively expressed on spleen and bone marrow–derived murine dendritic cells. These authors postulate that some of the unique functions of dendritic cells could be attributed to PD-L2 expression. Further studies will be necessary to sort out these discrepancies in expression patterns. Interestingly, mitogen or TCR activation of murine and human T cells results in cell surface expression of PD-L1 in addition to PD-1 (73) (L.

These mice spontaneously developed a lupus-like disease with age (69). At 6 months, PD-1-deficient mice displayed elevated serum IgG3 levels and increased IgG3 and C3 deposition in the glomeruli. At 14 months, approximately 50% of these mice had lupus-like glomerulonephritis and histological evidence of arthritis as well as granulomatous inflammation. Introduction of the lpr mutation (B6-lpr/lpr-PD-1−/− ) accelerated the onset and severity of disease. Thus, PD-1 deficiency in the C57BL/6 background resulted in the development of a late onset, chronic, progressive, lupuslike glomerulonephritis and arthritis, and the severity of disease was exacerbated by the absence of FAS-mediated apoptosis.

Rev. Immunol. 20:29-53. org by HINARI on 09/01/07. For personal use only. 2 (63). The PD-1 cytoplasmic domain contains two tyrosines, with the most membrane-proximal tyrosine (VAYEEL in mouse PD-1) located within an ITIM (immuno-receptor tyrosinebased inhibitory motif) (62). The presence of an ITIM on PD-1 strongly suggested that this molecule could function to attenuate antigen receptor signaling by recruitment of cytoplasmic phosphatases (64). Human and murine PD-1 proteins share 60% amino acid identity with conservation of four potential N-glycosylation sites, and residues that define the Ig-V domain (65, 66).

Download PDF sample

Rated 4.46 of 5 – based on 6 votes