By Alister G. Craig, Artur Scherf
The subject of antigenic version is critical in either biology and medication. it truly is of large curiosity, because it describes the process(es) wherein microorganisms 'shift shape', by means of genetic rearrangement or in a different way. In scientific phrases, this has an incredible impression at the infectious ailment strategy, because the immune process has nice hassle in maintaining with this change, and therefore getting rid of the infectious agent. Antigenic version is an incredible technique in which microbes steer clear of the immune reaction, and persist within the body.The wide scope of the ebook appeals to all these operating within the box of infectious illness, immunology of an infection, pathogenesis, molecular biology and in addition to evolutionary biologists. subject matters coated contain not just bacterial species, and viruses equivalent to influenza, HIV, Rotavirus, but additionally eukaryotic parasites - some of the most interesting teams of organisms displaying this behaviour. entire assurance of antigenic version from viruses to parasitesDiscussions dedicated to molecular mechanisms of host evasionDetailed descriptions of host/pathogen interactions
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Extra resources for Antigenic Variation
Feline calicivirus was first identified in domestic cats in 1957. It is a relatively easy virus to study in the laboratory in that, unlike some other caliciviruses, it grows readily in feline cell cultures. The pathogenesis of the disease has also largely been determined since infections can easily be established under defined experimental conditions in specific-pathogen-free cats. The natural history of the disease in its host has also been well studied, the virus being a highly successful pathogen that is widespread in the cat population.
Hughes, S. H. and Varmus, H. E. (1997) Retroviruses. Cold Spring Harbor Laboratory Press. Drake, J. W. and Holland, J. J. (1999) Proc. Natl Acad. Sci. USA 96, 13910–13913. Easteal, S. (1992) BioEssays 14, 415–419. Elena, S. , Gonzalez-Candelas, F. and Moya, A. (1992) J. Mol. Evol. 35, 223–229. , Capobianchi, M. , Ameglio, F. and Dianzani, F. (1995) AIDS 9, 329–335. , Robertson, D. , Rodenburg, C. , Michael, S. , Cummins, L. , Arthur, L. , Shaw, G. , Sharp, P. M. and Hahn, B. H. (1999) Nature 397, 436–441.
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